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Tissue engineered stents created from chondrocytes.

G E Amiel1, J J Yoo, B S Kim

  • 1Laboratory for Tissue Engineering and Cellular Therapeutics, Department of Urology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

The Journal of Urology
|May 24, 2001
PubMed
Summary
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Engineered cartilage stents show promise for treating genitourinary strictures. This biocompatible tissue engineering approach offers a potential new solution for urethral and ureteral reconstruction.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Urethral and ureteral strictures can result from trauma, surgery, or instrumentation.
  • Current treatments for stricture disease have limitations.
  • Autologous tissue-engineered stents offer potential biocompatibility advantages.

Purpose of the Study:

  • To investigate the feasibility of engineering cartilage stents in vitro and in vivo.
  • To assess the potential of using chondrocyte-seeded polymer scaffolds for genitourinary tract applications.

Main Methods:

  • Polymer scaffolds (polyglycolic acid mesh with polylactic-co-glycolic acid coating) were fabricated.
  • Bovine chondrocytes were seeded onto scaffolds.
  • Scaffolds were cultured in vitro (bioreactors) and implanted in vivo (nude mice).

Related Experiment Videos

  • Evaluations included cytological analysis, collagen content, and mechanical durability.

    • Main Results:

    • Engineered stents exhibited a cartilaginous appearance with confirmed cartilage, collagen, and glycosaminoglycan deposition.
    • In vivo stents showed increased collagen and glycosaminoglycan deposition.
    • Biomechanical testing confirmed elasticity and high pressure resistance.

    Conclusions:

    • The study demonstrates the feasibility of creating cartilaginous stents using chondrocyte-seeded polymer matrices.
    • This tissue engineering technology shows potential clinical utility for treating genitourinary stricture disease.