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Related Experiment Videos

Aspartame effect in sickle cell anemia.

C V Manion1, J Howard, B Ogle

  • 1Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73112, USA.

Clinical Pharmacology and Therapeutics
|May 24, 2001
PubMed
Summary

Aspartame demonstrated potential in reducing sickled cells in vitro and in vivo. Further studies are recommended to confirm its efficacy for sickle cell anemia treatment and crisis prevention.

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Area of Science:

  • Biochemistry
  • Hematology

Background:

  • Aspartame, an artificial sweetener, interacts with Bence Jones proteins.
  • Its phenylalanine component may interfere with sickle hemoglobin polymerization.

Purpose of the Study:

  • To investigate the in vitro and in vivo effects of aspartame.
  • To determine aspartame's efficacy in treating sickle cell anemia.

Main Methods:

  • In vitro: Aspartame (1-2 mg/mL) added to sickle cell anemia patient blood samples; sickled cells counted.
  • In vivo: Randomized single-dose aspartame administration (1.5-6 mg/kg) to sickle cell anemia patients; blood samples analyzed over 24 hours.

Main Results:

  • In vitro: Aspartame reduced sickled cells from 28% to <14% at 1 mg/mL, with greater reduction at 2 mg/mL.

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  • In vivo: Oral aspartame decreased sickled cells in patients with HbSS anemia; 6 mg/kg inhibited sickling for at least 6 hours in 15 subjects.

    • Conclusions:

    • Aspartame shows promise in reducing sickled cells.
    • Further research is warranted to evaluate aspartame for sickle cell crisis and prevention.