Related Experiment Video
Updated: Oct 7, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
[Relationship between insulin resistance and pregnancy induced hypertension]
1Department of Obstetrics and Gynecology, Shanghai First People's Hospital, Shanghai 200080, China.
Objective:
To investigate whether insulin resistance is a cause of pregnancy induced hypertension (PIH).
Methods:
All patients who had abnormal 50 g glucose screening test accepted 75 g oral glucose tolerance test (OGTT) and insulin sensitive index (ISI) was calculated. These patients were followed up and divided into two groups (PIH group and normal pregnancy group) at third trimester of pregnancy. The difference of ISI between the PIH group and normal pregnancy group was compared.
Results:
Fast blood glucose, fast blood insulin and ISI were (4.2 +/- 0.7) mmol/L vs. (3.8 +/- 0.7) mmol/L, (107.8 +/- 48.8) pmol/L vs. (50.4 +/- 40.5) pmol/L, and -3.25 +/- 0.27 vs. -2.58 +/- 0.66 in PIH group and normal group, respectively (P < 0.05). The areas under the curve of insulin were 1,125.6 +/- 331.0 and 1,057.6 +/- 442.2 in PIH group and normal pregnancy group, respectively (P > 0.05).
Conclusions:
Insulin resistance during second trimester of pregnancy may be one of the causes of pregnancy induced hypertension.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type II Diabetes II: Pathophysiology
Hormonal Regulation
Type II Diabetes I: Introduction
Diabetes Mellitus: Introduction
