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[Studies on the chemical constituents of Kaempferia marginata]
1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100094, China.
Aim:
To study the chemical constituents of the rhizomes of Kaempferia galanga L. (Zingiberaceae).
Methods:
Various chromatographic techniques were used to separate and purify. Their physico-chemical properties and spectral data were used to elucidate the structures.
Results:
Six compounds were isolated from the hexane extract of K. galanga. Their structures were identified as marginatol (1), 8 (14), 15-sanderacopimaradiene-1 alpha, 9 alpha-diol (2), 8 (14), 15-sanderacopimaradiene-1 alpha, 6 beta, 9 alpha-triol (3), germacrone (4), trans-ethyl p-methoxycinnamate (5) and n-pentadecane (6) on the basis of spectral data (IR, MS, 1H-1H, 13C-1H NMR, NOEs and HMBC).
Conclusion:
Marginatol (1) is a new isopimarene diterpenoid and was elucidated as 8(14), 15-isopimaradiene-6 alpha-ol. Compounds 2, 3 and 4 were isolated for the first time from this plant.