Related Experiment Video
Updated: Oct 7, 2026
Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
[Studies on melatonin gelatin microspheres for intranasal administration]
1Department of Pharmaceutics, Shenyang Pharmaceutic University, Shenyang 110015, China.
Aim:
To increase the bioavailability of melatonin (MT), MT gelatin microspheres (MT-GMS) for intranasal administration were prepared.
Methods:
MT-GMS were prepared using emulsifying-cross linking technique. Orthogonal tests were used to optimize the preparation conditions. The residence time of technetium-99m (99mTc) labeled gelatin microspheres (GMS) in the nasal cavity of rabbits as compared to gelatin solution, was investigated using gamma scintigraphy. Furthermore the bioavailability in rabbits was examined for evaluating MT-GMS.
Results:
The mean diameter of MT-GMS was 50.2 microns, the particle size focused on 30-70 microns. The drug content was 13.48%. The release profile in vitro showed sustained effect. The residence time of GMS in the nasal cavity of rabbits was longer than that of gelatin solution. After intranasal administration in rabbits, the bioavailability of MT-GMS was 87.47% as compared to vein injection, while the bioavailability of MT solution was 69.72%.
Conclusion:
MT-GMS prepared could meet the needs of intranasal administration, and could increase the bioavailability of MT.
More Related Videos
05:44Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
05:50Intranasal Delivery of mRNA Polyplexes via Rayleigh Breakup Aerosols: An In Vitro Method for Nasal Deposition and Functional Testing
Published on: January 20, 2026