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Hemostatic changes in patients with malignancy.

G H Goldsmith1

  • 1James Graham Brown Cancer Center, University of Louisville, Kentucky, USA.

International Journal of Hematology
|May 25, 2001
PubMed
Summary

Cancer significantly impacts blood clotting (hemostasis), causing biochemical changes in nearly all patients. This can lead to clinical thrombosis or bleeding, necessitating a review of these complex interactions.

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Area of Science:

  • Oncology
  • Hematology

Background:

  • Malignant diseases frequently alter hemostasis.
  • Nearly all cancer patients show biochemical hemostatic changes.
  • Some patients develop clinical thrombosis or hemorrhage.

Purpose of the Study:

  • To review the relationship between neoplasia and hemostasis.
  • To discuss thrombotic and bleeding complications in cancer patients.

Main Methods:

  • Literature review of intravascular coagulation and fibrinolysis.
  • Review of thrombocytopenia and thrombocytosis in cancer.
  • Analysis of direct and indirect interactions between neoplasms and hemostasis.

Main Results:

  • Neoplasms affect all hemostatic components.
  • Rare thrombotic and hemorrhagic events arise from direct neoplasm-hemostasis interactions.
  • Autoimmune and thrombotic microangiopathic syndromes are discussed.

Conclusions:

  • Neoplasia profoundly affects hemostasis, leading to diverse clinical syndromes.
  • Understanding these interactions is crucial for managing cancer-related bleeding and clotting.
  • Further research into neoplasia-hemostasis interplay is warranted.

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