Related Experiment Videos
Synthesis and biological evaluation of cytogenin derivatives
N Matsumoto1, T Nakashima, K Isshiki
1Central Research Laboratories, Mercian Corp, Johnan, Fujisawa, Japan. n-matsumoto@hkg.odn.ne.jp
The Journal of Antibiotics
|May 25, 2001
Abstract:
To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. It modified collagen-induced arthritis in mice. It also showed potent anti-angiogenic activity in a mouse dorsal air sac assay.