[Post-vaccination granuloma due to aluminium hydroxide]
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A L Bordet1, P Michenet, C Cohen
1Service d'anatomie et de cytologie pathologiques, CHR d'Orléans, Hôpital de la Source, BP 6709, 45067 Orléans Cedex 2.
Abstract:
Post-vaccination granulomas a well-known reaction due to aluminium adsorbed vaccines. We report three cases of children who developed subcutaneous nodules at the site of a previous injection of Tetracoq*vaccine (tetanus, diphtheria, Bordetella pertussis, poliovirus). Histologically, the lesions were characterized by a necrotizing granulomatous reaction with eosinophilic crystalline material. This material stained positively with the solochrome cyanine stain and was pink-purple. This aluminium stain enabled diagnosis of post-immunization injection-site reaction due to aluminium.
