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Updated: Aug 12, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
[Changes in the blood coagulation system in pregnancy]
1Zentrum für Innere Medizin, Medizinische Klinik IV, Klinikstr. 36, 35385 Giessen. Bettins.Kemkes-Matthes@innere.med.uni-giessen.de
Abstract:
Extensive alterations of the coagulation system occur during pregnancy: Increasing levels of coagulation factors and continuous decrease of coagulation inhibitor protein S contribute to the increase of prothrombotic potential. Moreover, enhanced activation of coagulation factors, platelets and fibrinolytic system can be demonstrated by determination of activation parameters like prothrombin fragment F 1 + 2, beta-thromboglobulin and D-dimer. The alterations in the coagulation system are one cause for the enhanced thromboembolic risk during pregnancy.
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