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[Murine models for human diseases].

F Benavides1, J L Guénet

  • 1Department of Carcinogenesis, Science Park, M.D. Anderson Cancer Center, University of Texas, Park Road 1C, P.O. Box 389, Smithville, Texas 78957, USA. fbenavides@sprd1.mdacc.tmc.edu

Medicina
|May 26, 2001
PubMed
Summary

Mouse models, including spontaneous, induced, and genetically engineered mutations, are crucial for understanding human genetic diseases and developing therapies. Advances will increase their availability for functional genome analysis in the post-genomic era.

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Area of Science:

  • Genetics
  • Genomics
  • Translational Medicine

Context:

  • Mouse models have been historically vital for studying human genetic diseases.
  • Technological advancements are rapidly expanding the toolkit for creating and utilizing mouse models.
  • The "post-genomic" era necessitates sophisticated models for functional genome analysis.

Purpose:

  • To provide a bibliographic review of mouse mutations as models for human genetic diseases.
  • To highlight the historical and future significance of mouse models in biomedical research.
  • To emphasize the role of mouse mutants in functional genomics.

Summary:

  • This review covers spontaneous, induced, and genetically engineered mouse mutations used as models for human genetic diseases.
  • Mouse models have been instrumental in elucidating disease pathogenesis and guiding therapeutic development.

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  • Future technological and mutagenesis screening advances will significantly enhance the availability and utility of mouse models.

    • Impact:

    • Accelerated understanding of human genetic disease mechanisms.
    • Facilitation of novel therapeutic strategies and drug discovery.
    • Enabling comprehensive functional analysis of the human and mouse genomes.