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Related Experiment Videos

Treatment regimen and hypnotic self-administration.

T Roehrs1, A Bonahoom, B Pedrosi

  • 1Henry Ford Hospital, Sleep Disorders and Research Center, 2799 West Grand Blvd, Detroit, MI 48202, USA.

Psychopharmacology
|May 26, 2001
PubMed
Summary

Insomniacs self-administer more hypnotics, but treatment regimens did not alter this behavior. Sleep quality, not drug type, predicted subsequent capsule use, suggesting therapy-seeking rather than drug abuse.

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Psychophysiology·2002

Area of Science:

  • Behavioral Science
  • Clinical Psychology
  • Pharmacology

Background:

  • Previous research indicates insomniacs frequently self-administer hypnotic medications.
  • The influence of prior treatment regimens on this self-administration behavior remains unclear.

Purpose of the Study:

  • To investigate if different treatment regimens (capsule availability and instructions) affect hypnotic self-administration rates in individuals with and without insomnia.
  • To determine if self-administration patterns are indicative of therapy-seeking behavior or drug abuse.

Main Methods:

  • Sixty-four healthy adults (32 with insomnia, 32 without) participated.
  • Participants underwent 11 nights of enforced treatment regimens (daily, as-needed, or every third night).
  • Following this, a 14-night choice phase involved self-administering either placebo or triazolam (0.25 mg).

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Main Results:

  • Insomniacs self-administered more capsules than non-insomniacs; triazolam was preferred over placebo.
  • Treatment regimens had minimal impact on overall capsule self-administration.
  • Sleep quality ratings predicted subsequent capsule self-administration, irrespective of whether the capsule contained triazolam or placebo.

Conclusions:

  • Hypnotic self-administration in insomniacs appears to be driven by a desire for therapeutic relief.
  • The findings support the interpretation of this behavior as therapy-seeking, rather than indicative of drug abuse.