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Novel cytotoxic 4-phenylfuranocoumarins from Calophyllum dispar
D Guilet1, J J Hélesbeux, D Séraphin
1SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, F-49100 Angers, France.
Journal of Natural Products
|May 26, 2001
Abstract:
Eight new 4-phenylfuranocoumarins (1-8) have been isolated from the stem bark and the fruits of Calophyllum dispar, together with three known coumarins. The structures of 1-8 were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these furanocoumarins exhibited significant cytotoxic activity against KB cells.