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Naphthopyranone glycosides from Paepalanthus microphyllus
S Piacente1, L Campaner Dos Santos, N Mahmood
1Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo 84084, Fisciano, SA, Italy.
Journal of Natural Products
|May 26, 2001
Summary
Three new naphthopyranone glycosides were isolated from Paepalanthus microphyllus and tested for anti-HIV activity. These natural compounds showed potential in inhibiting HIV-1MN replication in C8166 cells.
Area of Science:
- Natural Product Chemistry
- Virology
- Pharmacology
Background:
- Paepalanthus microphyllus is a plant source of bioactive compounds.
- Natural products are explored for antiviral properties, particularly against Human Immunodeficiency Virus (HIV).
Purpose of the Study:
- To isolate and characterize novel naphthopyranone glycosides from Paepalanthus microphyllus.
- To evaluate the anti-HIV activity of isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via mass spectrometry (electrospray ionization) and Nuclear Magnetic Resonance (NMR) spectroscopy (1D and 2D).
- In vitro anti-HIV activity assay using C8166 cells infected with HIV-1MN.
Main Results:
- Three new naphthopyranone glycosides (compounds 1-3) and one known compound (compound 4) were isolated.
- Compounds were structurally characterized using advanced spectroscopic methods.
- Compounds 1-4 were screened for their inhibitory effects against HIV-1MN.
Conclusions:
- Paepalanthus microphyllus yielded novel naphthopyranone glycosides.
- The isolated compounds were fully characterized.
- The study contributes to the search for natural anti-HIV agents.