Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alloantigen-induced specific immunological unresponsiveness.

K J Wood1, N D Jones, A R Bushell

  • 1Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. kathryn.wood@nds.ox.ac.uk

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|May 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ex vivo-expanded human CD19<sup>+</sup>TIM-1<sup>+</sup> regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis.

Nature communications·2022
Same author

Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation.

mAbs·2018
Same author

Quantification of CD4(+) T Cell Alloreactivity and Its Control by Regulatory T Cells Using Time-Lapse Microscopy and Immune Synapse Detection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Demethylation of the TSDR is a marker of squamous cell carcinoma in transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

The role of donor-specific HLA alloantibodies in liver transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same journal

The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Natural microcosms in ecology: fulfilling the promise of model systems?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
See all related articles

Alloantigen exposure can induce immune unresponsiveness, crucial for transplantation. Understanding immune response mechanisms guides novel tolerance strategies for clinical application.

Area of Science:

  • Immunology
  • Transplantation Science

Background:

  • The immune system's response to alloantigen is complex and context-dependent.
  • Alloantigen administration can induce specific unresponsiveness (tolerance) in vivo.
  • Understanding the molecular basis of immune response outcomes is key to manipulating them.

Purpose of the Study:

  • To review alloantigen-induced immunological unresponsiveness.
  • To explore how mechanisms of unresponsiveness inform tolerance induction strategies.

Main Methods:

  • Review of existing literature on alloantigen recognition and immune response modulation.
  • Analysis of molecular mechanisms governing immune activation versus unresponsiveness.
  • Examination of novel tolerance induction strategies derived from mechanistic insights.

Related Experiment Videos

Main Results:

  • Alloantigen encounters trigger diverse immune responses influenced by presentation context.
  • Therapeutic strategies involving alloantigen administration can induce specific unresponsiveness.
  • Insights into molecular pathways are driving the development of new tolerance induction methods.

Conclusions:

  • Manipulating the immune system via alloantigen exposure requires a deep understanding of underlying molecular mechanisms.
  • Novel tolerance induction strategies show promise for future clinical transplantation.
  • Further research into alloantigen-induced unresponsiveness is critical for advancing transplantation outcomes.