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Updated: Oct 7, 2026

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
Published on: June 29, 2015
New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biology
C Patterson1, G A Stouffer, N Madamanchi
1Program in Molecular Cardiology and Department of Medicine, Lineberger Comprehensive Cancer Center and Center for Thrombosis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7075, USA. cpatters@med.unc.edu
Abstract:
Thrombin is a serine protease that potently activates platelets and catalyzes the conversion of fibrinogen to fibrin. Thrombin also exerts direct effects on vascular cells, such as smooth muscle cells, via interactions with members of the protease-activated receptor family. Evidence in several animal models implicates thrombin-mediated signaling events in the response to injury that typifies vascular lesion formation in atherosclerosis and restenosis. In this review, we examine the activation of protease-activated receptors by thrombin, the downstream signaling events mediated by these receptors, and the physiological role of thrombin in vascular cells and vascular disease.
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