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Published on: July 31, 2019
New crystal forms of Trypanosoma cruzi dUTPase
M Harkiolaki1, A M Brzozowski, D Gonzalez-Pacanowska
1Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, England.
Abstract:
The dUTPase from Trypanosoma cruzi has been crystallized in two crystal forms, both belonging to space group P6(3)22, with unit-cell parameters a = b = 134.67, c = 148.66 A (form I, two molecules per asymmetric unit) and a = b = 136.43, c = 68.71 A (form II, one molecule per asymmetric unit). Single-wavelength data have been collected using synchrotron radiation to 3.0 A for crystal form I and to 2.4 A for crystal form II and structure solution is under way. T. cruzi dUTPase is a potential target for anti-protozoan drug design.
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