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Updated: Aug 9, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Estimation of aqueous solubility in drug design

J Huuskonen1

  • 1Division of Pharmaceutical Chemistry, Department of Pharmacy, POB 56, IN-00014 University of Helsinki, Finland. jarmo.huuskonen@helsinki.fi

Combinatorial Chemistry & High Throughput Screening
|May 29, 2001
PubMed

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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