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Andropause--a multisystem disease.

J P Heaton1, A Morales

  • 1Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.

The Canadian Journal of Urology
|May 29, 2001
PubMed
Summary
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Aging men experiencing androgen deficiency, or andropause, may show accelerated aging symptoms. Treatment involves testosterone replacement therapy to improve quality of life and hormone levels.

Area of Science:

  • Endocrinology
  • Gerontology
  • Men's Health

Background:

  • Androgen deficiency syndrome in aging men, termed andropause, presents with significant biochemical and clinical changes.
  • These changes reflect a broader hormonal imbalance involving interconnected systems like growth hormone, IGF-I, melatonin, and leptin.
  • Symptoms manifest across various domains, including body composition, skin, cognitive function, mood, sleep, sexual health, and prostate function.

Purpose of the Study:

  • To outline the clinical and biochemical characteristics of androgen deficiency in aging men.
  • To identify the key clinical domains affected by this condition.
  • To describe the current diagnostic and therapeutic approaches for andropause.

Main Methods:

  • Clinical assessment of presenting complaints related to aging and hormonal changes.

Related Experiment Videos

  • Biochemical investigation, primarily measuring serum bioavailable testosterone levels.
  • Review of current treatment modalities, focusing on testosterone replacement therapy.

    • Main Results:

    • Androgen deficiency is associated with accelerated aging and impacts multiple physiological systems.
    • Treatment with testosterone replacement aims to normalize hormone levels and improve clinical symptoms.
    • Effective treatment can lead to improvements in lean body mass, fat distribution, bone density, mood, and sexual function.

    Conclusions:

    • Andropause is a complex syndrome resulting from interconnected hormonal system dysregulation.
    • Testosterone replacement therapy is a viable treatment option for eligible men.
    • Contraindications for testosterone therapy include a history of prostate or breast cancer.