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Related Experiment Videos

LI-cadherin gene expression during mouse intestinal development.

B Angres1, L Kim, R Jung

  • 1Institut für Laboratoriumsmedizin und Pathobiochemie, Charite, Campus Virchow-Klinikum, Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12200 Berlin, Germany. bmangres@clontech.com

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|May 29, 2001
PubMed
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Liver-Intestine cadherin (LI-cadherin) is crucial for intestinal development in mice, with its expression coinciding with villi formation and tissue remodeling. This cell adhesion molecule is exclusively found in the intestinal epithelium during embryogenesis.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Adhesion

Background:

  • LI-cadherin (Liver-Intestine cadherin) is a 7-D cadherin involved in cell-cell adhesion.
  • Its physiological role in vivo remains largely unexplored despite in vitro studies.
  • Understanding LI-cadherin's function is key to comprehending tissue development and integrity.

Purpose of the Study:

  • To investigate the physiological function and expression pattern of mouse LI-cadherin in vivo.
  • To characterize LI-cadherin's role during mouse embryogenesis and in adult tissues.
  • To compare mouse LI-cadherin expression with its rat counterpart.

Main Methods:

  • Isolation of mouse LI-cadherin cDNA.
  • Generation of specific antibodies against overexpressed LI-cadherin.

Related Experiment Videos

  • Analysis of LI-cadherin expression in adult mouse tissues and embryos using antibody-based methods.

    • Main Results:

    • Mouse LI-cadherin shares high sequence identity (91%) with rat LI-cadherin.
    • In adult mice, LI-cadherin is expressed in the intestine and spleen, but not the liver.
    • During embryogenesis (from E12.5), LI-cadherin is primarily detected in the intestinal epithelium, coinciding with villi formation, and is co-expressed with E-cadherin.

    Conclusions:

    • Mouse LI-cadherin plays a significant role in intestinal development and tissue remodeling during embryogenesis.
    • Its expression pattern is largely restricted to the intestinal epithelium, differing from rat LI-cadherin expression in the liver.
    • LI-cadherin is a key component of the intestinal epithelial cell adhesion complex during development.