Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytopathic hypoxia in sepsis: a true problem?

M P Fink1

  • 1University of Pittsburgh Medical School, Division of Critical Care Medicine, Anesthesiology and Critical Care Medicine, 3550 Terrace Street, Room 616 Scaife Hall, Pittsburgh, PA 15261, USA. finkmp@anes.upmc.edu

Minerva Anestesiologica
|May 29, 2001
PubMed
Summary

Sepsis-induced organ dysfunction stems from impaired cellular energy production, a condition called cytopathic hypoxia. Nuclear enzyme poly-ADP-ribosyl polymerase (PARP) activation is identified as a key driver of this energy deficit.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Organized staffing directed by intensivists improves outcomes for critically ill patients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
Same author

Ethyl pyruvate therapy attenuates experimental severe arthritis caused by type II collagen (CII) in the mouse (CIA).

International journal of immunopathology and pharmacology·2011
Same author

Ethyl pyruvate: a novel anti-inflammatory agent.

Journal of internal medicine·2007
Same author

Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2006
Same author

Ethyl pyruvate: a novel treatment for sepsis and shock.

Minerva anestesiologica·2004
Same author

Mechanisms of organ dysfunction in critical illness: report from a Round Table Conference held in Brussels.

Intensive care medicine·2002

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Pathophysiology

Background:

  • Sepsis frequently leads to organ dysfunction.
  • Cellular energy production is crucial for organ function.
  • The precise mechanisms behind sepsis-induced cellular dysfunction are not fully understood.

Purpose of the Study:

  • To investigate the underlying causes of organ dysfunction in sepsis.
  • To elucidate the role of cellular energy metabolism in sepsis.
  • To identify key molecular players involved in sepsis-induced cellular damage.

Main Methods:

  • Studied cellular oxidative adenosine triphosphate (ATP) production in sepsis models.
  • Investigated the phenomenon termed 'cytopathic hypoxia'.
  • Examined the role of nuclear enzyme poly-ADP-ribosyl polymerase (PARP) activation.

Related Experiment Videos

Main Results:

  • Organ dysfunction in sepsis is partly due to impaired cellular ATP production.
  • This impairment is characterized as 'cytopathic hypoxia'.
  • Activation of PARP is a significant factor contributing to cytopathic hypoxia in sepsis.

Conclusions:

  • Cytopathic hypoxia, driven by PARP activation, is a critical mechanism in sepsis-induced organ dysfunction.
  • Targeting PARP may offer a therapeutic strategy for sepsis.
  • Understanding cellular energy derangements is key to treating sepsis complications.