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Cytogenetic study of six cases of radiation-induced meningiomas
H Zattara-Cannoni1, P Roll, D Figarella-Branger
1Cytogenetic Oncology Laboratory, C.H.U. Timone-Marseille 264, Rue Saint-Pierre, 13385, Marseille Cedex 5, France.
Cancer Genetics and Cytogenetics
|May 30, 2001
Abstract:
It is known that, following radiotherapy, secondary cancer may occur after a long latent period. Few cytogenetic studies have been reported on tumors of the central nervous system occurring after radiotherapy. We report the cytogenetic study of six cases of radiation-induced meningiomas. In all cases, we observed the same chromosome abnormality, der(1)(1qter-->1p11::22q12-->22pter). SKY and CGH techniques allowed us to identify the chromosomal abnormalities. We suggest that a gene localized on 1p13 is involved in radiation-induced meningiomas.