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Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain

T Ohman1, S L King, A Krithivas

  • 1Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, 1202 Abramson, 3516 Civic Center Boulevard, 19104-4318, Philadelphia, PA, USA.

Virus Research
|May 30, 2001
PubMed

Echoviruses (EV) 1 and 8 were originally considered to be distinct serotypes, but more recently have been considered strains of the same virus. In experiments with chimeric recombinant fusion proteins, both viruses bound to the I domain of the integrin VLA-2, and both required the same receptor residues for attachment. A full-length, infectious cDNA clone encoding EV1 was obtained; its nucleotide sequence was determined, as were the sequences encoding the EV8 capsid. EV1 and 8 show 94% amino acid identity within the capsid region and are more similar to each other than to any other human picornavirus.

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