A validated flame AAS method for determining magnesium in a multivitamin pharmaceutical preparation

Area of Science:

• Analytical Chemistry
• Pharmaceutical Analysis

Background:

• Accurate quantification of magnesium in multivitamin preparations is crucial for pharmaceutical quality control.
• Existing methods may lack the speed and efficiency required for routine analysis.

Purpose of the Study:

• To develop and validate a rapid and reliable method for determining magnesium content in multivitamin pharmaceutical preparations.
• To assess the method's performance characteristics, including linearity, precision, accuracy, and robustness.

Main Methods:

• Flame atomic absorption spectrometry (FAAS) was employed after acid dissolution of the multivitamin samples.
• Method validation included linearity, precision (repeatability and reproducibility), accuracy (recovery studies), and robustness testing.
• Detection and quantification limits were determined.

Main Results:

• The method demonstrated excellent linearity (correlation coefficient ≥ 0.9999) over the tested concentration range (0.05–0.40 mg/L).
• High precision was achieved with relative standard deviations (R.S.D.) of 0.6% for repeatability and 1.1–1.6% for reproducibility.
• Mean recoveries ranged from 98.9% to 100.8%, indicating high accuracy. Robustness testing showed minimal variation (R.S.D. 0.2–0.5%).
• Detection and quantification limits were 3.8 and 7.0 µg/g, respectively.

Conclusions:

• The validated FAAS method is suitable for the direct and accurate measurement of magnesium in water-soluble multivitamin pharmaceutical preparations.
• This rapid method offers a reliable tool for quality control in the pharmaceutical industry.