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Lipase catalysed synthesis of optically enriched alpha-haloamides
A Azim1, S K Sharma, C E Olsen
1Department of Chemistry, University of Delhi, Delhi-110 007, India.
Bioorganic & Medicinal Chemistry
|May 30, 2001
Abstract:
An efficient lipase catalysed synthesis of optically enriched alpha-halogenated amides with concomitant optical enrichment of the starting alpha-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.