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Repression of MHC determinants in HIV infection
S Kanazawa1, B Matija Peterlin
1Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143-0703, USA.
Microbes and Infection
|May 30, 2001
Abstract:
HIV infects CD4(+) macrophages and lymphocytes. Before the development of AIDS, HIV weakens the immune system in part by blocking antigen processing and presentation via major histocompatibility complex (MHC) molecules. In this report, we discuss how HIV escapes the immune surveillance by MHC II molecules.