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Automation of measurements and data evaluation in biomolecular NMR screening
1Dept for Biostructural Research (PRBT), Grenzacher Str., CH-4070, Basel, Switzerland
Drug Discovery Today
|May 30, 2001
Abstract:
This article reviews the equipment required for biomolecular screening applications in the automated preparation of samples and the acquisition of a large number of NMR data sets. New hardware connecting lab-bench and NMR spectrometers is introduced. In addition, the article focuses on software used for the automated processing of data and the calculation of similarity between spectra - a prerequisite for the identification of test compounds interacting with a target molecule.