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Related Experiment Videos

Cholinergic mechanisms in central thermoregulation in pigeons.

N Chawla, M B Johri, P N Saxena

    British Journal of Pharmacology
    |March 1, 1975
    PubMed
    Summary

    Acetylcholine and carbachol cause central hyperthermia in pigeons. Atropine and tubocurarine modulate these effects, revealing distinct cholinergic pathways in temperature regulation.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Physiology

    Background:

    • Cholinergic neurotransmission plays a role in central thermoregulation.
    • Understanding the specific receptor subtypes involved is crucial for elucidating these pathways.

    Purpose of the Study:

    • To investigate the central effects of acetylcholine (ACh) and related compounds on cloacal temperature in pigeons.
    • To differentiate the roles of muscarinic and nicotinic receptors in central thermoregulation.

    Main Methods:

    • Unanesthetized pigeons were administered acetylcholine, carbachol, atropine, and (+)-tubocurarine via intraventricular or intravenous injection.
    • Cloacal temperature was monitored at ambient temperatures of 19-25°C.

    Main Results:

    • Intraventricular acetylcholine or carbachol induced hyperthermia, sometimes followed by hypothermia.
    • Atropine induced hypothermia and blocked ACh/carbachol hyperthermia, suggesting nicotinic receptor involvement.
    • (+)-Tubocurarine induced hyperthermia and blocked ACh/carbachol hypothermia, suggesting muscarinic receptor involvement.

    Conclusions:

    • Cholinergic neurons in the central thermoregulatory pathway influence body temperature.
    • Atropine's hypothermic effect may unmask continuously released ACh acting on nicotinic receptors.
    • (+)-Tubocurarine's hyperthermic effect may unmask continuously released ACh acting on muscarinic receptors.

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