Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical detection of between-group differences in event-related potentials.

A Achim1

  • 1Centre de Neuroscience de la Cognition, Université du Québec à Montréal, C.P. 8888, Succursale Centre-Ville, Montreal, Quebec H3C 3P8, Canada. achim.andre@uqam.ca

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|May 30, 2001
PubMed
Summary

A new statistical method, Projection onto Centroids Difference Vectors with permutations (PCDVp), effectively compares event-related potentials (ERPs) even with limited data. This sensitive approach enhances the analysis of neurophysiological signals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidental Discovery of Multiple Myeloma, Presenting as an Amyloid Tumor with Plasmacytic Elements of the Thoracic Wall.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2015
Same author

A clinical trial comparing pantoprazole and esomeprazole to explore the concept of achieving 'complete remission' in gastro-oesophageal reflux disease.

Alimentary pharmacology & therapeutics·2007
Same author

Refutation of Poffenberger's inference: an existence proof and a countermodel.

Brain and cognition·2001
Same author

Novel Bayesian multiscale method for speckle removal in medical ultrasound images.

IEEE transactions on medical imaging·2001
Same author

Emotional distress among couples involved in first-trimester induced abortions.

Canadian family physician Medecin de famille canadien·2000
Same author

Mismatch negativity: different water in the same river.

Audiology & neuro-otology·2000

Area of Science:

  • Neuroscience
  • Biostatistics
  • Signal Processing

Background:

  • Many event-related potential (ERP) analyses face statistical challenges due to insufficient sample sizes relative to the number of data points.
  • Traditional statistical methods often fail to meet the multivariate requirement of having more observations than variables.

Purpose of the Study:

  • To identify a sensitive statistical test for comparing two independent groups of ERPs.
  • To address the limitations of existing methods in scenarios with limited cases compared to measurements.

Main Methods:

  • Five simulation studies were conducted to evaluate different statistical approaches.
  • Simulated signal and noise waveforms were generated with varying parameters (e.g., number of trials, data point correlation, signal-to-noise ratio).

Related Experiment Videos

  • The false alarm rate and sensitivity of each method were assessed across 2000 simulated experiments per condition.

    • Main Results:

    • The initial 'Projection onto Centroids Difference Vectors' (PCDV) method showed promise but had an erratic false alarm rate.
    • A refined version, PCDVp, incorporating random permutations for significance assessment, demonstrated high sensitivity.
    • PCDVp achieved approximately 50% power at a signal-to-noise ratio of 1.0 and 90% power at 1.5 for comparing EEG-like waveforms with 48 trials each.

    Conclusions:

    • PCDVp is a sensitive and robust method for detecting differences between independent sets of waveforms.
    • The method requires no prior assumptions about the data.
    • PCDVp is applicable to various data types, including waveforms, topographies, and spatio-temporal data.