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Herpes simplex virus infections.

R J Whitley1, B Roizman

  • 1Department of Pediatrics, Microbiology, and Medicine, University of Alabama at Birmingham, Children's Hospital, 1600 7th Avenue South, Birmingham, AL 35233, USA. rwhitley@peds.uab.edu

Lancet (London, England)
|May 30, 2001
PubMed
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Herpes simplex virus (HSV) causes various human diseases, ranging from mild to life-threatening. Recent advances in understanding HSV molecular biology offer new insights into its pathogenesis and effective management strategies.

Area of Science:

  • Virology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Herpes simplex virus (HSV), a member of the herpesviridae family, has been recognized for centuries.
  • HSV infections in humans manifest in a spectrum of diseases, from mild mucocutaneous conditions to life-threatening illnesses.

Purpose of the Study:

  • To provide a contemporary review of Herpes simplex virus (HSV).
  • To interpret the biological properties, function, epidemiology, and treatment of HSV diseases.

Main Methods:

  • Literature review of recent advances in HSV molecular biology.
  • Synthesis of current knowledge on HSV pathogenesis and management.

Main Results:

  • Substantial advances in understanding HSV molecular biology over the past 50 years.

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  • Insights into the pathogenesis and management of HSV infections.

    • Conclusions:

    • A comprehensive understanding of HSV biological properties is crucial.
    • Current knowledge facilitates improved diagnosis and treatment of HSV diseases.