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The coatomer of Trypanosoma brucei
1Zentrum für Molekulare Biologie (ZMBH), Im Nevenheimer Feld 282, 69120, Heidelberg, Germany.
Molecular and Biochemical Parasitology
|May 30, 2001
Abstract:
Coatomer is a multisubunit complex involved in trafficking of vesicles between the endoplasmatic reticulum and the Golgi apparatus. From sequence homologies, all seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP, are encoded in the genome of Trypanosoma brucei. The complete predicted amino-acid sequences of beta-, beta'-, and zeta-COP show only 20-30% identity with higher eucaryotic homologues. The trypanosome coatomer complex was partially purified using a procedure similar to that used for bovine coatomer.