Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exiting the endoplasmic reticulum.

F S Gorelick1, C Shugrue

  • 1Department of Medicine, Yale University School of Medicine, Bldg. 27, GI Research, VACT HealthCare, 950 Campbell Avenue, West Haven, CT 06516, USA. fred.gorelick@yale.edu

Molecular and Cellular Endocrinology
|May 30, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice.

PloS one·2018
Same author

Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses.

American journal of physiology. Gastrointestinal and liver physiology·2012
Same author

Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell.

American journal of physiology. Gastrointestinal and liver physiology·2004
Same author

Synapsin I is expressed in epithelial cells: localization to a unique trans-Golgi compartment.

Journal of cell science·2001
Same author

Mechanisms of intracellular zymogen activation.

Bailliere's best practice & research. Clinical gastroenterology·2000
Same author

Early trypsinogen activation in acute pancreatitis.

The Medical clinics of North America·2000
Same journal

Female-specific metabolic genetic liability reveals a separable metabolic dimension of polycystic ovary syndrome.

Molecular and cellular endocrinology·2026
Same journal

The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.

Molecular and cellular endocrinology·2026
Same journal

G1 regulation of BK<sub>Ca</sub> channel leads to decreased migration of senescent pericytes and improved age-related hearing loss.

Molecular and cellular endocrinology·2026
Same journal

Maternal butyrate administration ameliorates fetal fatty liver and maternal metabolic alterations related to maternal obesity.

Molecular and cellular endocrinology·2026
Same journal

Sulforaphane preserves hepatocellular metabolic regulation and organelle integrity in a model of diet-induced obesity.

Molecular and cellular endocrinology·2026
Same journal

Patient-derived eutopic and ectopic endometrial stromal cells: characterization and development of immortalized lines.

Molecular and cellular endocrinology·2026
See all related articles

Vesicular transport relies on coat proteins like clathrin, COPI, and COPII. COPII coats are essential for budding from the endoplasmic reticulum (ER) and ER-to-Golgi transport, with mutations linked to human diseases.

Area of Science:

  • Cell biology
  • Molecular biology
  • Biochemistry

Background:

  • Nascent protein transport involves vesicular movement through cellular compartments.
  • Vesicle biogenesis is regulated by proteins controlling budding, transport, docking, and fusion.
  • Cytoplasmic coat proteins mediate distinct steps in vesicular transport.

Purpose of the Study:

  • To review the roles of different coat protein complexes in vesicular transport.
  • To highlight the specific functions of COPII coats in ER-to-Golgi trafficking.
  • To underscore the clinical relevance of COPII vesicle proteins.

Main Methods:

  • Literature review of key studies on vesicular transport and coat proteins.
  • Analysis of the functions of clathrin, COPI, and COPII coat complexes.

Related Experiment Videos

  • Examination of recent findings on the link between COPII proteins and human diseases.

    • Main Results:

    • Clathrin coats are involved in endocytosis and lysosome biogenesis.
    • COPI coats mediate retrograde transport within the Golgi and to the ER.
    • COPII coats drive anterograde transport from the ER, including cargo selection.

    Conclusions:

    • COPII coats are crucial for ER budding and ER-to-Golgi transport.
    • COPII proteins concentrate cargo within budding vesicles.
    • Mutations in COPII vesicle proteins are associated with human diseases.