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Decreased hippocampal BDNF expression after acute systemic injection of quinpirole
F Fumagalli1, R Santero, M Gennarelli
1Center of Neuropharmacology, Institute of Pharmacological Sciences University of Milan, Via Balzaretti 9, 20133, Milan, Italy.
Neuropharmacology
|May 30, 2001
Abstract:
We report that acute quinpirole injection reduces BDNF mRNA levels in the rat hippocampus both at 2 and 6 h after the administration. These results suggest that the neurotrophin expression may be inhibited by situations involving dopaminergic overactivity.