Related Experiment Video

Updated: Aug 11, 2026

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Short-term penicillin-V prophylaxis did not prevent acute otitis media in infants

M Foglé-Hansson1, P White, A Hermansson

  • 1Department of Otorhinolaryngology, S-541 85 Central Hospital, Skövde, Sweden. margaretha.fogle-hansson@vgregion.se

International Journal of Pediatric Otorhinolaryngology
|May 30, 2001
PubMed

Insights

Short-term penicillin V treatment during upper respiratory tract infections did not prevent recurrent acute otitis media in young children. This study found no significant difference in acute otitis media episodes between the penicillin V and placebo groups.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pharmacology

Background:

  • Recurrent acute otitis media (AOM) is common in young children.
  • Identifying effective preventive strategies for AOM is crucial.

Purpose of the Study:

  • To evaluate if short-term penicillin V prophylaxis during upper respiratory tract infections (URTIs) prevents recurrent AOM in children under six months old.

Main Methods:

  • A prospective, double-blind, placebo-controlled study involved 70 children with a first AOM episode before six months of age.
  • Penicillin V or placebo was administered by parents during subsequent URTIs.
  • Children were followed for 12 months with otomicroscopy and bimonthly check-ups.

Main Results:

  • A total of 304 URTI episodes were treated across both groups.
  • No statistically significant difference was observed in the number of AOM episodes between the penicillin V and placebo groups.

Conclusions:

  • Prophylactic, short-term penicillin V initiated during URTIs does not effectively prevent recurrent acute otitis media in young children.
  • Further research may be needed to explore alternative or more sustained preventive measures.
Abstract

More Related Videos

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Probiotic Studies in Neonatal Mice Using Gavage10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Related Concept Videos

Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...