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The acidocalcisome.

R Docampo1, S N Moreno

  • 1Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA. rodoc@uiuc.edu

Molecular and Biochemical Parasitology
|May 30, 2001
PubMed
Summary
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The acidocalcisome is an acidic organelle storing polyphosphates and cations, crucial for parasite survival. This organelle aids microorganisms in adapting to environmental stress.

Area of Science:

  • Cell Biology
  • Parasitology
  • Biochemistry

Background:

  • Acidocalcisomes are electron-dense acidic organelles found in various microorganisms.
  • They contain pyrophosphate and polyphosphates complexed with cations like calcium.
  • Their role in parasite physiology is not fully understood.

Purpose of the Study:

  • To elucidate the function and pathway association of acidocalcisomes.
  • To investigate the role of acidocalcisomes in microbial adaptation to stress.

Main Methods:

  • Analysis of organelle structure and composition.
  • Investigation of membrane transport mechanisms.
  • Comparative studies in trypanosomatids and apicomplexan parasites.

Main Results:

Related Experiment Videos

  • Acidocalcisomes are distinct from the endocytic pathway, potentially branching from the secretory pathway.
  • They possess specific pumps and exchangers for cation and polyphosphate transport.
  • These organelles are implicated in cation and polyphosphate storage.

Conclusions:

  • Acidocalcisomes play a vital role in storing essential molecules for microorganisms.
  • They contribute significantly to the adaptation mechanisms of parasites facing environmental challenges.
  • Further research into acidocalcisomes can reveal new therapeutic targets.