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Synthesis and hydrolytic stability studies of albendazole carrier prodrugs
F Hernández-Luis1, A Hernández-Campos, L Yépez-Mulia
1Departamento de Farmacia, Facultad de Química, UNAM, C.U. D.F. 04510, Mexico, Mexico. franher@servidor.unam.mx
Bioorganic & Medicinal Chemistry Letters
|May 30, 2001
Abstract:
Three N-acyl (2, 3, and 4), two N-alkoxycarbonyl (5 and 6), and one N-acyloxymethyl (7) derivatives of albendazole (1) have been prepared and assessed as potential prodrugs. The determination of the aqueous solubility and partition coefficient, as well as the conversion of these derivatives to 1 in buffer solution, human plasma, and pig liver esterase were determined.