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A new Antennapedia-derived vector for intracellular delivery of exogenous compounds
C García-Echeverría1, L Jiang, T M Ramsey
1Oncology Research, Novartis Pharma Inc., CH-4002, Basel, Switzerland. carlos.garcia-echeverria@pharma.novartis.com
Bioorganic & Medicinal Chemistry Letters
|May 30, 2001
Abstract:
We describe the design, synthesis and cell translocation capacity of a peptide derived from the third alpha-helix of the homeodomain of Antennapedia. The new sequence appears to be an efficient and nontoxic means to deliver a covalently linked peptide cargo into cells.