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Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands
1Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. hh285@columbia.edu
Bioorganic & Medicinal Chemistry Letters
|May 30, 2001
Abstract:
A series of dopamine D(4) antagonists was synthesized and evaluated as potential candidates for development as positron emission tomography (PET) radioligands. All new compounds display high affinity and selectivity for the D(4) receptors and compounds 5b, 5d, and 5e were identified as candidates for radioligand development.