Jove
Visualize
Contact Us

Related Experiment Videos

Human populations show reduced DNA sequence variation at the factor IX locus.

E E Harris1, J Hey

  • 1Universidade de São Paulo, Cidade Universitaria, Departamento de Biologia, Instituto de Biociências, Rua do Matão-Travessa 14 number 321, CEP 05508-900, São Paulo, Brazil. eeharris@ib.usp.br

Current Biology : CB
|May 30, 2001
PubMed
Summary

Human DNA sequence variation differs greatly between genes. Studies show the Factor IX (FIX) gene has exceptionally low variation compared to other genes like PDHA1, suggesting unique evolutionary pressures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

10-Year Clinical Comparative Study of Ceramic and Composite Veneered Metal Crowns.

The European journal of prosthodontics and restorative dentistry·2021
Same author

Retentive characteristics of individual and prefabricated polyvinylsiloxane overdenture attachments: alternative treatment options for geriatric patients.

Clinical oral investigations·2018
Same author

Implementing a new curriculum for computer-assisted restorations in prosthetic dentistry.

European journal of dental education : official journal of the Association for Dental Education in Europe·2017
Same author

Performance of chromID® CARBA medium for carbapenemases-producing Enterobacteriaceae detection during rectal screening.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2013
Same author

[Radiation-related caries: etiology and possible preventive strategies. What should the radiotherapist know?].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2011
Same author

Hydrolysis of wood cellulose and decomposition of sugar in dilute phosphoric acid.

The Journal of physical and colloid chemistry·2010
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Human genetics
  • Population genetics
  • Molecular evolution

Background:

  • Human DNA sequence variation exhibits significant locus-specific differences.
  • Comparing genetic loci across diverse populations is crucial for accurate variation studies.
  • Previous studies often used different population samples, complicating direct comparisons.

Purpose of the Study:

  • To investigate DNA sequence variation in the Factor IX gene (FIX) across diverse Old World populations.
  • To compare FIX variation with another X-linked gene, PDHA1, using similar population samples.
  • To understand the evolutionary history and potential selective pressures on the FIX gene region.

Main Methods:

  • Sequencing of intron 4 of the Factor IX gene (FIX) in diverse Old World populations.

Related Experiment Videos

  • Comparative analysis of FIX sequence data with existing data for the PDHA1 gene.
  • Estimation of nucleotide diversity, effective population size, and time to most recent common ancestry.

    • Main Results:

    • FIX exhibits significantly lower DNA sequence variation among humans compared to PDHA1.
    • Nucleotide diversity at FIX is the lowest recorded for non-Y chromosome nuclear genes.
    • FIX suggests a smaller effective population size and a more recent common ancestry compared to PDHA1.
    • Analyses indicate potential recent positive or background selection acting on the FIX region.

    Conclusions:

    • Genomic regions can have vastly different evolutionary histories, even with minimized sampling differences.
    • The low variation in FIX suggests recent positive selection or background selection.
    • Understanding locus-specific evolutionary dynamics is critical in human population genetics.