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Substance p.

S Harrison1, P Geppetti

  • 1Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Via Fossato Di Mortara 19, 44100, Ferrara, Italy. selena.harrison@dns.unife.it

The International Journal of Biochemistry & Cell Biology
|May 30, 2001
PubMed
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Substance P, a neuropeptide, plays a key role in chronic inflammation and pain. Targeting substance P (SP) with agonists and antagonists offers potential treatments for diseases like asthma, migraine, and inflammatory bowel disease.

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Substance P (SP) is a neuropeptide discovered in the 1930s.
  • SP is released from primary afferent nerve endings.
  • SP is implicated in chronic inflammation and pain pathways.

Purpose of the Study:

  • To provide an overview of the history and functional role of Substance P.
  • To explore the therapeutic potential of Substance P receptor modulators.
  • To highlight the role of SP in various disease models.

Main Methods:

  • Review of historical data on Substance P.
  • Analysis of studies involving Substance P receptor agonists and antagonists.
  • Examination of research utilizing transgenic mouse models.

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Main Results:

  • Substance P antagonists show efficacy in models of asthma, inflammatory bowel disease, migraine, and pain.
  • The development of SP modulators provides a framework for understanding SP's function.
  • Transgenic mice offer new avenues for exploring SP's role.

Conclusions:

  • Substance P is a critical mediator in numerous chronic inflammatory conditions.
  • Targeting Substance P offers promising therapeutic strategies for diverse diseases.
  • Further research into SP, agonists, and antagonists could yield significant clinical solutions.