Commentary: possible mechanisms for strand-breaks in DNA induced by stirring
1The Bone and Joint Research Unit St. Bartholomews Hospital School of Medicine London EC1M 6BQ, UK.
Free Radical Research
|May 30, 2001
Abstract:
When aqueous solutions of DNA are stirred at room temperature, strand breaks occur extensively. Using various spin-traps, coupled with epr spectroscopy, we have shown that this does not proceed via homolysis. It is suggested that breaks occur by hydrolysis at strongly bent regions, momentarily induced by the stirring.
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