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t(2;5) associated with a histiocytic-monocytic neoplasm
A Lemes1, S De La Iglesia, C Santana
1Department of Haematology and Histopathology, Hospital Universitario de Gran Canaria 'Doctor Negrín'. Las Palmas de Gran Canaria. alemeas@correo.hpino.rcanaria.es
Abstract:
We describe a patient with a neoplasm derived from the histiocytic-monocytic lineage associated with t(2;5) detected by FISH. The patient presented with bone marrow involvement, no organomegaly and subsequently developed a leukaemic picture. The clinical course was aggressive and the patient died four months from diagnosis. Cell morphology, immunophenotype (CD30-, EMA-, Lisozyme+, cy CD68+ and CD45+) and DNA analysis showing germ-line configuration of the Ig/TCR chain genes ruled out the diagnosis of anaplastic large cell lymphoma (ALCL). This unusual case ilustrates that t(2;5) is not exclusive for ALCL but may be found in a few cases of rare neoplasms derived from the histiocytic-monocytic cells.