Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SMR-type multidrug resistance pumps.

Y J Chung1, M H Saier

  • 1Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA.

Current Opinion in Drug Discovery & Development
|May 31, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing Fractional Quantum Hall States at Even-Denominator Fillings 1/6 and 1/8.

Physical review letters·2025
Same author

Origin of Pinning Disorder in Magnetic-Field-Induced Wigner Solids.

Physical review letters·2024
Same author

Signatures of Correlated Defects in an Ultraclean Wigner Crystal in the Extreme Quantum Limit.

Physical review letters·2024
Same author

Outcome of Contemporary Nonsurgical Endodontic Retreatment: A Systematic Review of Randomized Controlled Trials and Cohort Studies.

Journal of endodontics·2024
Same author

Fractional Quantum Hall State at Filling Factor ν=1/4 in Ultra-High-Quality GaAs Two-Dimensional Hole Systems.

Physical review letters·2024
Same author

Moving Crystal Phases of a Quantum Wigner Solid in an Ultra-High-Quality 2D Electron System.

Physical review letters·2023

Multidrug resistance efflux pumps, particularly the small multidrug resistance (SMR) family, are key to antimicrobial resistance. This review details their structure and function in Bacillus subtilis, highlighting areas for future research.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Biochemistry

Background:

  • Multidrug resistance (MDR) efflux pumps are critical in pathogenic microorganisms, reducing the efficacy of antimicrobial drugs.
  • These efflux pumps are phylogenetically linked to five superfamilies of transport systems.

Purpose of the Study:

  • To review the drug/metabolite transporter (DMT) superfamily, focusing on the small multidrug resistance (SMR) protein family.
  • To describe the characteristics and encoding genes of SMR efflux pumps, particularly in Bacillus subtilis.

Main Methods:

  • Phylogenetic analyses were employed to classify efflux pump superfamilies.
  • Detailed examination of SMR protein homologs within the Bacillus subtilis genome.

Main Results:

Related Experiment Videos

  • Identified five superfamilies of transport systems associated with MDR efflux pumps.
  • Highlighted the SMR family within the DMT superfamily, noting the presence of multiple homologs in Bacillus subtilis.
  • Discussed the potential for homo- and hetero-oligomeric pump formation, including those exporting cationic drugs.

Conclusions:

  • The SMR family plays a significant role in multidrug resistance.
  • Bacillus subtilis possesses eight SMR homologs, contributing to its resistance mechanisms.
  • Further investigation into SMR pump anomalies and unanswered questions is crucial for developing new antimicrobial strategies.