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Updated: Sep 3, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Sideropenic anemia in infants and toddlers]
G Jakovljević1, A Votava-Raić, D Tjesić-Drinković
1Klinicki bolnicki centar Zagreb, Klinika za pedijatriju, Zavod za djecju hematologiju i onkologiju.
Insights
Iron-deficiency anemia is common in infants, often linked to poor nutrition and rapid growth. Early screening and better parent education are crucial for preventing severe cases and the need for blood transfusions.
Area of Science:
- Pediatrics
- Hematology
- Nutritional Science
Context:
- Iron-deficiency anemia is the most prevalent anemia in infants, frequently encountered in routine pediatric care.
- Multiple infant factors, including low birth weight, rapid growth, and inadequate nutrition, contribute to its development.
- The study analyzed data from 119 pediatric patients treated between 1994 and 1999.
Purpose:
- To analyze the factors contributing to iron-deficiency anemia in infants.
- To evaluate the effectiveness of current diagnostic and treatment approaches.
- To identify areas for improved parental counseling and iron deficiency prophylaxis.
Summary:
- Analysis of 119 infants with iron-deficiency anemia revealed significant contributing factors such as inadequate nutrition (e.g., flour-based diets) and insufficient iron prophylaxis.
- Seven-point-seven percent of patients required erythrocyte concentrate transfusions due to severe anemia and anemic hypoxia.
- Prenatal/perinatal history, socioeconomic conditions, and prior oral iron use were also assessed.
Impact:
- Highlights the need for increased attention to infant iron deficiency anemia.
- Emphasizes the importance of enhanced parental education regarding nutrition and iron supplementation.
- Underscores the necessity for more effective screening protocols for early detection and intervention.
Abstract:
Iron-deficiency anemia is the most common anemia in infants. In the routine pediatric care this problem is encountered every day. Numerous factors in infancy (low birth weight, rapid growth, insufficient nutrition) are involved in the development of iron-deficiency anemia, and they must be considered when establishing diagnosis, counselling parents, and prescribing oral iron preparations. Data on 119 patients aged up to two years treated in the Division of Gastroenterology and Nutrition, Pediatric Department, University Hospital Centre Zagreb Salata between 1994 and 1999, were analyzed. We were prompted to do so because of great frequency of iron-deficiency anemia as one of associated diagnoses, and unfortunately often the only diagnosis requiring hospitalization. Out of 119 patients with iron-deficiency anemia, nine (7.7%) patients (four premature newborns and three from twin pregnancy) had to receive transfusion of erythrocyte concentrate due to very bad general condition and low red blood count, accompanied by clinical signs of anemic hypoxia. We also analyzed prenatal and perinatal history, socioeconomic living conditions of these children, i.e. their nutrition, and if they had previously received oral iron preparations. Some of the results, such as inadequate alimentation with flour, as well as insufficient prophylaxis of iron deficiency, which were found in most cases of severe anemia, point to the need of paying greater attention to this problem, better parents education, and more adequate screening for iron deficiency anemia.
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