Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroprotection in acute stroke.

H C Chua1, P Y Ng

  • 1Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433. hoe_chin_chua@notes.ttsh.gov.sg

Annals of the Academy of Medicine, Singapore
|May 31, 2001
PubMed
Summary

Recent advances in neuroprotection show promise for acute stroke treatment. While human trials are ongoing, neuroprotective agents aim to minimize brain injury and improve outcomes for stroke patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and mortality of sepsis in Hong Kong between 2009 and 2018 based on electronic health records: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Cross-specialty point-of-care ultrasound education in The University of Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Ten-year territory-wide trends in the utilisation and clinical outcomes of extracorporeal membrane oxygenation in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2023
Same author

Upper Respiratory Tract Infection Trends in a Psychiatric Institute in Singapore.

East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan·2022
Same author

Successfully conducting an objective structured clinical examination with real patients during the COVID-19 pandemic.

Hong Kong medical journal = Xianggang yi xue za zhi·2021
Same author

The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.

Science advances·2020

Area of Science:

  • Neuroscience
  • Cerebrovascular Research
  • Pharmacology

Background:

  • Central nervous system neurons are vulnerable to ischemic and hemorrhagic damage.
  • The ischemic cascade presents multiple targets for therapeutic intervention.
  • Neuroprotective agents aim to reduce cellular injury and preserve brain tissue.

Purpose of the Study:

  • To review recent advancements in neuroprotection for acute stroke.
  • To identify potential therapeutic targets in the ischemic cascade.
  • To evaluate the efficacy of neuroprotective agents in human stroke.

Main Methods:

  • Conducted a MEDLINE search from January 1985 to November 2000.
  • Included keywords: neuroprotection, cerebrovascular, subarachnoid hemorrhage, perioperative stroke, hypothermia, apoptosis.
  • Reviewed clinical studies, review articles, and abstracts in English.

Main Results:

  • Thrombolysis is the only established treatment improving clinical outcomes in cerebral ischemia.
  • Neuroprotective therapies show efficacy in animal models but not yet in humans.
  • Nimodipine is effective for aneurysmal subarachnoid hemorrhage; new drug development is ongoing.

Conclusions:

  • Neuroprotection holds significant potential for improving stroke patient outcomes.
  • Ongoing clinical trials are evaluating new neuroprotective drug candidates.
  • Further research is crucial to translate animal model success into human clinical benefits.

Related Experiment Videos