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Prostate specific antigen in the Nigerian African.
F M Abbiyesuku1, O B Shittu, O O Oduwole
1Department of Chemical Pathology, University College Hospital, Ibadan, Ibadan, Nigeria.
African Journal of Medicine and Medical Sciences
|May 31, 2001
Summary
This study analyzed prostate-specific antigen (PSA) levels in Nigerian Africans, finding age correlates with PSA. Elevated PSA levels were observed in prostate cancer and benign prostatic hyperplasia (BPH) patients.
Area of Science:
- Urology
- Biochemistry
- Oncology
Background:
- Prostate-specific antigen (PSA) is a key biomarker for prostate health.
- Understanding PSA levels in diverse populations is crucial for accurate diagnosis.
- Previous studies highlight age-related PSA variations and its association with prostate conditions.
Purpose of the Study:
- To investigate the biological characteristics of PSA in a Nigerian African population.
- To establish reference ranges and identify correlations with age and prostate conditions.
- To evaluate PSA levels in healthy individuals, prostate cancer patients, and those with benign prostatic hyperplasia (BPH).
Main Methods:
- A cross-sectional study involving 214 Nigerian Africans: 59 healthy men, 58 prostate cancer patients, 81 BPH patients, and 16 women.
- Serum PSA levels were measured and analyzed.
- Statistical analysis was performed to determine correlations between PSA, age, and disease status.
Main Results:
- A significant positive correlation was found between age and serum PSA levels (r = 0.523; P = 0.001).
- Median PSA in healthy controls was 0.7 ug/L; 98.3% had < 4 ug/L.
- Median PSA in BPH patients was 8.5 ug/L; in prostate cancer patients, it was 92.6 ug/L.
- Detectable PSA values were found in 25% of women, with undetermined causes.
Conclusions:
- PSA trends in the Nigerian African population align with global findings.
- Age is a significant factor influencing PSA levels.
- Further research on prostate gland volume and evaluation of detectable PSA in women is warranted.