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The statistical comparison of clinical trials
1Department of Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA.
Abstract:
Being able to compare clinical trials using statistically proven analyses is essential, but certain protocols must be followed if such a comparison is to be made. The difficulty of making meaningful statistical comparisons is illustrated in 5 clinical trials comparing atypical antipsychotics. Certain judgments can be made on the basis of internal and external validity, for example, but there are many other areas--effect size, for example--in which it is impossible to make any statistical comparisons across these trials because they were not conducted in a uniform fashion. In the final analysis, it is doubtful that the differences between atypical antipsychotics covered in these trials are greater than those due to chance.
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