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Erythrodermia induced by omeprazole
J Borrás-Blasco1, A Navarro-Ruiz, F Navarro-Blasco
1Pharmacy Service, Hospital General Universitario de Elche, Spain.
Summary
Omeprazole (OMP) can cause severe skin reactions like erythrodermia, even in patients with a good safety profile. Discontinuation of OMP led to symptom improvement, highlighting the need for vigilance in drug-induced dermatoses.
Area of Science:
- Dermatology
- Pharmacology
- Internal Medicine
Background:
- Gastroesophageal reflux disease (GERD) is commonly treated with proton pump inhibitors like omeprazole (OMP).
- Cutaneous adverse drug reactions (ADRs) can occur with any medication, necessitating careful monitoring.
- Erythrodermia is a severe, widespread inflammatory skin condition.
Observation:
- A 58-year-old woman developed erythrodermia after initiating omeprazole therapy for GERD.
- The patient had a history of scleroderma, Sjögren's syndrome, and other conditions.
- Skin biopsy confirmed a toxicodermic reaction, strongly suggesting omeprazole as the causative agent.
Findings:
- Discontinuation of omeprazole resulted in significant improvement of the erythrodermia and the patient's general health.
- The case highlights a potential, though rare, adverse drug reaction associated with omeprazole.
- This emphasizes the importance of considering drug-induced causes in erythrodermia presentations.
Implications:
- Healthcare providers should consider omeprazole as a potential cause of erythrodermia, especially in patients with risk factors.
- Vigilance for cutaneous ADRs is crucial, even with medications known for their safety.
- Caution is advised when prescribing omeprazole to elderly patients or those with renal or hepatic compromise.