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Calcium absorption as a function of calcium intake.

R P Heaney, P D Saville, R R Recker

The Journal of Laboratory and Clinical Medicine

|June 1, 1975

Summary

Calcium absorption in adults shows a complex relationship with dietary intake. Absorption increases with intake, with no upper limit found, suggesting a component independent of regulatory mechanisms.

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Area of Science:

Human Physiology
Nutritional Science
Biochemistry

Background:

Dietary calcium intake is a critical determinant of calcium balance.
Understanding the relationship between calcium intake and absorption is essential for nutritional recommendations.
Previous studies suggest an inverse relationship between calcium absorption efficiency and intake.

Purpose of the Study:

To quantitatively evaluate the relationship between ingested calcium and absorbed calcium in adult humans.
To determine if an upper limit to calcium absorption capacity exists.
To describe the absorption kinetics mathematically.

Main Methods:

Absorption was assessed in 180 adult humans using concurrently administered oral and intravenous calcium isotopes.
Calcium intake ranged from 0.163 to 7.48 grams per day.
A mathematical model was developed to describe the absorption-intake relationship.

Main Results:

Calcium absorption (Ca Abs) followed a curvilinear relationship with intake (Ca-D), described by a specific equation.
The contribution of an exponential absorption component diminished at higher intakes (above 0.8 Gm/day).
Above 2-3 Gm/day, absorption became a linear function of intake, with no detectable upper limit observed.

Conclusions:

Calcium absorption is influenced by intake in a complex, non-linear manner.
A portion of calcium absorption appears to be independent of physiological control mechanisms and directly related to intake.
The findings suggest that calcium absorption capacity may be higher than previously assumed, even at very high intake levels.

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