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Related Experiment Videos

cAMP response element modulator (CREM): an essential factor for spermatogenesis in primates?

R Behr1, G F Weinbauer

  • 1University of Pennsylvania School of Medicine, Department of Genetics, Clinical Research Building, Curie Boulevard, Philadelphia, USA.

International Journal of Andrology
|May 31, 2001
PubMed
Summary

The cAMP-responsive element modulator (CREM) activator is crucial for sperm development. Abnormal CREM expression in men indicates issues with spermatid maturation, highlighting its essential role in primate testes.

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Area of Science:

  • Reproductive biology
  • Molecular endocrinology
  • Gene regulation

Background:

  • The cAMP-responsive element modulator (CREM) is a transcription factor involved in testicular gene expression.
  • Alternate promoter usage and splicing generate both repressor and activator forms of CREM.
  • CREM activators are vital for spermatid maturation, as shown in mouse models.

Purpose of the Study:

  • To investigate the role of CREM in mammalian spermatid development.
  • To compare CREM expression patterns across species, including humans.
  • To examine the association between CREM expression and spermatogenic disturbances in men.

Main Methods:

  • Gene-targeting studies in mice.
  • Analysis of testicular CREM expression in rodents, monkeys, and humans.

Related Experiment Videos

  • Examination of CREM expression and splicing in men with spermatogenic issues.

    • Main Results:

    • CREM activators are highly expressed in post-meiotic haploid germ cells.
    • Testicular CREM expression patterns are highly conserved across rodents, monkeys, and humans.
    • Abnormal CREM expression and splicing events correlate with spermatogenic disturbance and maturation arrest in men.
    • Numerous CREM target genes have been identified in haploid germ cells.

    Conclusions:

    • CREM plays a generally important role in mammalian spermatid development.
    • CREM is essential for spermatid maturation in the primate testis.
    • Altered CREM expression and splicing are linked to human spermatogenic failures.