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Uroguanylin level in umbilical cord blood
H Tsukahara1, K Sekine, M Uchiyama
1Department of Pediatrics, Fukui Medical University, Fukui, Japan. htsuka@fmsrsa.fukui-u.ac.jp
Background:
Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine.
Methods:
To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality.
Results:
Mean (+/- SD) cord plasma uroguanylin concentrations (8.8 +/- 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality.
Conclusion:
These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.